Abstract
Thermodynamic stability alone is insufficient to establish the feasibility of a hereditary polymer. Even if a tetra-stranded genetic architecture is energetically favorable under defined conditions, its biological relevance depends critically on kinetic accessibility. In this work, I develop a kinetic framework for Q-DNA, a canonical tetra-stranded hereditary polymer, and analyze the Q↔D interconversion problem through the lens of nucleationtheory, free-energy barriers, and metastability. I show that Q-DNA may occupy regions of parameter space where it is thermodynamically stable yet kinetically inaccessible, and I define strategies—environmental and molecular—for overcoming these barriers. This framework yields accessibility–stability maps that render tetra-stranded heredity experimentally testable and falsifiable.
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