The concept of Quantum-π proposes that the mathematical constant π governs not only geometrical symmetries, but also the energy quantization, probability structure, and electronic organization of molecular and condensed-matter systems. To transform this theoretical framework into a testable scientific proposal, I outline a set of realistic experimental strategies capable of revealing π-driven signatures in chemical, optical, and electronic measurements. I identify measurable observables—including spectral line spacing, coherence envelopes, vibrational quantization patterns, electron delocalization metrics, and wavefunction normalization constants—that can be compared to π-predicted values with high precision. I also propose next-generation experimental platforms such as nanostructured potentials, π-sensitive interferometry, π-scaled vibrational spectroscopy, and electronic π-mode detection in polymers and 2D materials. This article presents a framework for validating Quantum-π in the laboratory, establishing a roadmap from theory to experimental physics and chemistry.